Program Focus
Spontaneous wiring and rewiring of circuits in our brain are largely regulated by the chemical messenger glutamate induced activation of complicated proteins known as NMDA receptors. We identify chemical tools to understand the complexity and to reduce disease burden of anomalies.
Selected Publications
Costa, B. M.; Feng, B.; Tsintsadze, T. S.; Morley, R. M.; Irvine, M. W.; Tsintsadze, V.; Lozovaya, N. A.; Jane, D. E.; Monaghan, D. T., N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse. J Pharmacol Exp Ther 2009, 331 (2), 618-26. DOI: 10.1124/jpet.109.156752
Costa, B. M.; Irvine, M. W.; Fang, G.; Eaves, R. J.; Mayo-Martin, M. B.; Laube, B.; Jane, D. E.; Monaghan, D. T., Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid. Neuropharmacology 2012, 62 (4), 1730-6. DOI: 10.1016/j.neuropharm.2011.11.019
Costa, B. M.; Irvine, M. W.; Fang, G.; Eaves, R. J.; Mayo-Martin, M. B.; Skifter, D. A.; Jane, D. E.; Monaghan, D. T., A novel family of negative and positive allosteric modulators of NMDA receptors. J Pharmacol Exp Ther 2010, 335 (3), 614-21. DOI: 10.1124/jpet.110.174144
Irvine, M. W.; Costa, B. M.; Dlaboga, D.; Culley, G. R.; Hulse, R.; Scholefield, C. L.; Atlason, P.; Fang, G.; Eaves, R.; Morley, R.; Mayo-Martin, M. B.; Amici, M.; Bortolotto, Z. A.; Donaldson, L.; Collingridge, G. L.; Molnar, E.; Monaghan, D. T.; Jane, D. E., Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors. J Med Chem 2012, 55 (1), 327-41. DOI: 10.1021/jm201230z
Irvine, M. W.; Costa, B. M.; Volianskis, A.; Fang, G.; Ceolin, L.; Collingridge, G. L.; Monaghan, D. T.; Jane, D. E., Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors. Neurochem Int 2012, 61(4), 593-600. DOI:10.1016/j.neuint.2011.12.020