L. Preston Wade Professor, Department of Biomedical Engineering and Mechanics
Program Focus
Bioelectromechanical Systems is a cross disciplinary field that combines engineering and science from the nano to the macro level. In our laboratory, we have developed technology for tissue viability detection, picoliter sample management, and imaging for molecular medicine. Using electrical feedback to perform complex procedures in biotechnology with precision and control, we have established robust methods for single cell analysis, selective cell concentration, and cancer therapy.
Selected Publications
AR Hyler, NC Baudoin,MS Brown, MA Stremler, D Cimini, RV Davalos,, EM Schmelz, Fluid shear stress impacts ovarian cancer cell viability, subcellular organization, and promotes genomic instability.PloS one,2018.
S Bhonsle, M Lorenzo, A Safaai-Jazi, RV Davalos,. Characterization of Nonlinearity and Dispersion in Tissue Impedance during High Frequency Electroporation.IEEE Transactions on Biomedical Engineering,2017.(IF 3.577)
T Miklovic, EL Latouche, MR DeWitt, RV Davalos, MB Sano. A comprehensive characterization of parameters affecting high-frequency irreversible electroporation lesions.Annals of Biomedical Engineering,2017.(IF 3.221)
B Mercadal, CB Arena, RV Davalos,A Ivorra. Avoiding nerve stimulation in irreversible electroporation: a numerical modeling study. Physics in Medicine and Biology.2017
TJ O’Brien, C Arena, RV Davalos Thermal Considerations with Tissue Electroporation. In Handbook of Thermal Science and Engineering. pp 1-31, 2017.
EM Wasson, JW Ivey, SS Verbridge, RV Davalos. The feasibility of enhancing susceptibility of glioblastoma cells to IRE using a calcium adjuvant. Annals of Biomedical Engineering, pp 1-13. 2017 (IF 3.221)
M Bonakdar, PM Graybill, RV Davalos. A microfluidic model of the blood–brain barrier to study permeabilization by pulsed electric fields. RSC Advances. vol 7(68), pp 42811-42818, 2017.
EL Latouche, MB Sano, MF Lorenzo, RV Davalos, RC Martin II. Irreversible electroporation for the ablation of pancreatic malignancies: A patient specific methodology. Journal of Surgical Oncology, vol 115(2). In print, 2017. (IF 3.151)
JW Ivey, EL Latouche, ML Richards, GJ Lesser, W Debinski, RV Davalos, SS Verbridge. Enhancing irreversible electroporation by manipulating cellular biophysics with a molecular adjuvant. Biophysical Journal, vol 113(2), pp 472-480, 2017. (IF 3.972)
JH Rossmeisl, K Hall-Manning, JL Robertson, JN King, RV Davalos, W Debinski, S Elankumaran. Expression and activity of the urokinase plasminogen activator system in canine primary tumors. OncoTargets and Therapy, vol 10, pp 2077-2085, 2017.
https://www.beam.vt.edu/about/person.php?name=Rafael.Davalos