Assistant Professor, Fralin Biomedical Research Institute
Program Focus
Dr. Lamouille's lab studies the molecular mechanisms and role of the tumor microenvironment in regulating cancer cell plasticity. In particular, the lab specializes in studying epithelial-mesenchymal transition (EMT), and cancer stem cell self-renewal and differentiation in glioblastoma, breast, and colon cancers. Our goal is to develop novel therapeutic strategies to prevent tumor recurrence and metastases in human cancer progression.
Selected Publications
Katsuno Y, Qin J, Oses-Prieto J, Wang H, Jackson-Weaver O, Zhang T, Lamouille S, Wu J, Burlingame A, Xu J, Derynck R. (2018). Arginine methylation of SMAD7 by PRMT1 in TGF-β-induced epithelial-mesenchymal transition and epithelial stem-cell generation. Journal of Biological Chemistry 293: 13059-72.
James CC, Zeitz MJ, Calhoun PJ, Lamouille S, Smyth JW. (2018). Altered translation initiation of Gja1 limits gap junction formation during epithelial-mesenchymal transition. Molecular Biology of the Cell 29(7): 773-880.
Murphy SF, Varghese RT, Lamouille S, Guo S, Pridham KJ, Kanabur P, Osimani AM, Sharma S, Jourdan J, Rodgers CM, Simonds GR, Gourdie RG, Sheng Z. (2016). Connexin 43 Inhibition Sensitizes Chemoresistant Glioblastoma Cells to Temozolomide. Cancer Research 76(1): 139-49.