Professor, Department of Biomedical Sciences & Pathobiology
Program Focus
The long-term goal of the Seleem lab is focused on developing new antimicrobials and improving delivery of drugs for the treatment of infectious diseases. The lab is also developing novel methods for early detection and identification of a single bacterium and fungus in a complex environment. Highly collaborative in nature, our research integrates bacteriology, mycology, molecular pathogenesis, immunology, medicinal chemistry, pharmacology, and animal models. Bringing together these different disciplines is essential for producing scientific and medical advances for difficult and critically important clinical problems such as antimicrobial drug discovery. Two drugs from our lab are currently in clinical trials for treatment of chronic skin and eye infections in dogs. Information gained from studying pet dogs with chronic skin and eye infections is expected to help the individual dog, other animals with the same type of infections, and potentially humans.
Selected Publications
G. Naclerio, N. Abutaleb, D. Li, M. N. Seleem, H. Sintim (2020). Ultrapotent inhibitor of Clostridioides difficile growth, which suppresses recurrence in vivo. 10.1021/acs.jmedchem.0c01198. Journal of Medicinal Chemistry.
Hagras M, Abutaleb NS, N. Elhosseiny, T. Abdelghany, M. N. Seleem, Mayhoub AS. (2020). Development of biphenylthiazoles exhibiting improved pharmacokinetics and potent activity against intracellular Staphylococcus aureus. 10.1021/acsinfecdis.0c00137. ACS Infectious Diseases.
Kaur J, Cao X, Abutaleb NS, Elkashif A, Graboski AL, Tarawneh AH, Bhardwaj A, AbdelKhalek A, M. N. Seleem, Flaherty DP. (2020). Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus. J. Med. Chem. 2020, 63, 17, 9540–9562.
M. G. Elnaggar, H. E. Eldesouky, Y. Pei, J. Park, H. Mohammad, Y. A. Hegazy, H. M. Tawfeek, A. A. Abdel-Rahman, A. E. Aboutaleb, M. N. Seleem, Y. Yeo. (2020). Antibacterial nanotruffles for treatment of intracellular bacterial infection. Biomaterials. 262, (2020),120344.
Abutaleb NS and M. N. Seleem. (2020). Auranofin, at clinically achievable dose, protects mice and prevents recurrence from Clostridioides difficile infection. Scientific Reports 10 (1), 1-8.
Mohammad, H., N. Abutaleb, M. N. Seleem. (2020). Auranofin Rapidly Eradicates Methicillin-resistant Staphylococcus aureus (MRSA) in an Infected Pressure Ulcer Mouse Model. Scientific Reports. 10 (1), 1-8 IF= 3.99.
Y. J. Seong, A. Mayhoub, H. Mohammad & M. N. Seleem. (2020). Repurposing fenamic acids drugs to combat multidrug-resistant Neisseria gonorrhoeae. Antimicrobial Agents and Chemotherapy. 64;7;2020.
M. Zhang, W. Hong, N. Abutaleb, J. Li, P. Dong, C. Zong, P. Wang, M. N. Seleem, J. Cheng. (2020). Rapid Determination of Antimicrobial Susceptibility by Stimulated Raman Scattering Imaging of D2O Metabolic Incorporation in a Single Bacterium. Advanced Science. 2020,2001452.
Hagras, M., Salama, E.A., Sayed, A.M M. N. Seleem & A. Mayhoub. (2020). Oxadiazolylthiazoles as novel and selective antifungal agents. European Journal of Medicinal Chemistry 189 (2020) 112046.
M. Magana; M. Pushpanathan, A. Santos L. Lense; M. Fernandez; A. Ioannidis; M. A GiulianottI; Y. Apidianakis; S. Bradfute; A. Ferguson; A. Cherkasov; M. N. Seleem; C. Pinilla; C. Fuente-Nunez; T. Lazaridis; T. Dai; R. A Houghten; R. E Hancock, G. Tegos (2020). The value of antimicrobial peptides in the age of resistance. The Lancet Infectious Diseases. 20, 9, 2020,216-230.
For complete list of publication please visit our google scholar:
https://scholar.google.com/citations?hl=en&user=wjSN5_AAAAAJ&view_op=list_works&sortby=pubdate